Figure 6.

Passive Avoidance test of behavioral inhibition, forced swim test and open field. (A) Female mice showed no difference in latency to cross to the dark compartment on Day 1. While female controls learned and inhibited their behavior, female mice with Dlx 5/6 GRKD had decreased latency to enter the dark compartment compared to controls on day 2. (B) There was no difference in latency from controls in male Dlx 5/6 GRKD mice on day 1 or day 2. (C–H) Females Dlx 5/6 GRKD mice showed no differences in (C) center time or (D) total locomotion in the open field. Female Dlx 5/6 GRKD showed no differences in (E) immobility in the forced swim test. Similarly, male Dlx 5/6 GRKD mice showed no differences in (F) center time or (G) total locomotion in the open field, and immobility (H) in the forced swim test *p ≤ 0.05; ^#p ≤ 0.05 for comparison of day within group.