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. Author manuscript; available in PMC: 2018 Dec 28.
Published in final edited form as: FEBS Lett. 2014 May 27;588(14):2185–2197. doi: 10.1016/j.febslet.2014.05.029

Fig. 2.

Fig. 2

3′-UTR consensus cis-elements of canonical and Star-PAP target 3′-UTRs. The canonical 3′-UTR has distinct consensus elements such as the AAUAAA poly(A) signal, cleavage site ~15–30 nucleotide downstream of PAS, G/GU rich DSE and a U-rich USE (for a review see Ref. [7]). In case of Star-PAP target mRNAs, except for the intact PAS (AAUAAA), they have suboptimal DSEs (deplete U sequence), and no regular USE present; instead, a GC-rich Star-PAP binding region is found around 40–50 nucleotides upstream of the cleavage site is present.