Skip to main content
. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Neuropharmacology. 2018 Sep 7;141:260–271. doi: 10.1016/j.neuropharm.2018.09.005

Figure 3. The effect of MMP-2200 on L-DOPA-induced AIMs.

Figure 3.

In the top panels, LAO AIMs scores are plotted and in the lower panels the L-DOPA-induced locomotor scores (contraversive rotations) are shown (7 mg/kg L-DOPA). Co-injection of (A) 10 mg/kg and (B) 20 mg/kg MMP- 2200 increases L-DOPA-induced LAO AIMs scores by ~10% (mean AIMs score ± SEM; n = 17–18; ** p < 0.01). Conversely, co-injection of (C) 10 mg/kg and (D) 20 mg/kg MMP-2200 led to a marked 50% decrease in L-DOPA-induced contraversive rotations compared to the l-DOPA- only vehicle control (mean AIMs score ± SEM; n = 14; ***p < 0.001, ** p < 0.01, * p < 0.05).