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. 2018 Dec 21;9:1841. doi: 10.3389/fphys.2018.01841

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Copyright © 2018 Siddiqa, Cirillo, Tareen, Ali, Kutmon, Eijssen, Ahmad, Evelo and Coort.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Presence of co-expressed genes of ANGPTL8 in the ANGPTL8 Regulatory Pathway (pathway id:WP3915 (www.wikipathways.org/instance/WP3915)). Thirteen genes in the ANGPTL8 regulatory pathway which are also identified to be co-expressed with it are marked with red color. These genes (MAPK8, CYP3A4, PIK3R2, PIK3R4, PRKAB2, ANGPTL8, G6PC, MAP3K11, FLOT1, PIK3C2G, SHC1, SLC16A2, RAPGEF1) belong to different signaling arms of the pathway. Among these genes, SHC1 and PIK3C2G are also identified as hub genes.