Table 3.
Top 10 pathways in gene-pathway co-expression network: The maximum number of ANGPTL8 associated co-expressed genes identified in WikiPathways along with respective gene symbols are listed.
| PID | PathwayName | Gene Count | Genes |
|---|---|---|---|
| WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway | 13 | MAPK8, CYP3A4, PIK3R2, PIK3R4, ANGPTL8, PRKAB2, G6PC, MAP3K11, FLOT1, PIK3C2G, SHC1, SLC16A2, RAPGEF1 |
| WP306 | Focal Adhesion | 13 | MAPK8, COL1A1, ACTN1, COL5A1, MET, PIK3R2, PIK3R4, ZYX, SHC1, COL3A1, PIP5K1C, ARHGAP5, RAPGEF1 |
| WP2882 | Nuclear Receptors Meta-Pathway | 12 | FGD4, SLCO1B1, UGT1A9, CYP3A4, ABCB11, BHLHE40, GCLM, PRDX6, BAAT, PPARGC1A, SLC19A2, IGFBP1 |
| WP3888 | VEGFA-VEGFR2 Signaling Pathway | 11 | MAPK8, FRS2, ATF6, PFN1, SHC1, PLCG1, PIK3R2, MYH9, GIPC1, RAPGEF1, CYP2C8 |
| WP481 | Insulin Signaling | 10 | PIK3C2G, MAPK8, INPP4A, SHC1, GYS2, PIK3R2, PIK3R4, RAPGEF1, MAP3K11, FLOT1 |
| WP3362 | Chromatin modifying enzymes | 10 | KDM6A, CARM1, SETD1A, SMARCA4, ELP2, TADA1, SMARCD1,CHD4, GATAD2A, JADE3 |
| WP702 | Metapathway biotransformation | 10 | UGT1A10, UGT1A9, CYP3A4, FMO4, GLYAT, BAAT, CYP4V2, HNMT, CYP2C8, NAA40 |
| WP2857 | Mesodermal Commitment Pathway | 9 | BMPR2, MBTD1, KDM6A, DIP2A, BHLHE40, EPB41L5, C9orf72, HPRT1, AXIN1 |
| WP3932 | Focal Adhesion-PI3K-Akt- mTOR-signaling pathway | 9 | COL1A1, COL5A1, COL3A1, MET,GYS2, PIK3R2, PIK3R4, GNG7,PPARGC1A |
| WP3925 | Amino Acid metabolism | 9 | CTH, MAOA, FH, GCLM, MCCC1, MUT, BHMT, HNMT, AUH |