Table 2 -.

Clinical surrogates compared between non-AA and AA recipients occurring during the first four years post-transplant for each of the four respective landmark analyses

Post-Transplant Clinical Surrogates	non- AA	AA	Odds-Ratio (95% CI)	p-Value*
Year One	n=413	n=587
Acute Rejection	5.8%	5.6%	0.97 (0.56–1.66)	0.899
Mean Glucose >160 mg/dL	20.3%	26.1%	1.38 (1.02–1.87)	0.036
Mean SBP >140 mmHg	47.2%	60.7%	1.72 (1.34–2.22)	<0.001
Mean Tacrolimus CV >40%	54.0%	56.2%	1.09 (0.85–1.41)	0.486
Mean Hemoglobin <10 gm/dL	22.5%	27.1%	1.28 (1.95–1.72)	0.101
Any of the Above Five Outcomes	82.1%	90.1%	1.99 (1.38–2.88)	<0.001
Year Two	n=171	n=297
Acute Rejection	1.2%	4.0%	3.56 (0.79–16.1)	0.079
Mean Glucose >160 mg/dL	18.7%	22.2%	1.24 (0.77–1.99)	0.369
Mean SBP >140 mmHg	33.9%	46.8%	1.71 (1.16–2.53)	0.007
Mean Tacrolimus CV >40%	21.6%	29.0%	1.48 (0.95–2.30)	0.083
Mean Hemoglobin <10 gm/dL	6.4%	7.1%	1.11 (0.52–2.35)	0.792
Any of the Above Five Outcomes	57.3%	68.1%	1.77 (1.20–2.62)	0.004
Year Three	n=132	n=228
Acute Rejection	1.5%	2.2%	1.46 (0.28–7.62)	0.654
Mean Glucose >160 mg/dL	17.4%	26.3%	1.69 (0.99–2.90)	0.054
Mean SBP >140 mmHg	37.1%	52.6%	1.88 (1.21–2.92)	0.005
Mean Tacrolimus CV >40%	21.2%	26.8%	1.35 (0.81–2.26)	0.240
Mean Hemoglobin <10 gm/dL	4.6%	5.7%	1.27 (0.47 −3.42)	0.636
Any of the Above Five Outcomes	56.1%	75.0%	2.35 (1.49–3.71)	<0.001
Year Four	n=114	n=189
Acute Rejection	0.0%	2.7%	NA**	0.080
Mean Glucose >160 mg/dL	18.4%	25.9%	1.55 (0.87 −2.75)	0.133
Mean SBP >140 mmHg	36.0 %	52.9%	2.00 (1.24–3.22)	0.004
Mean Tacrolimus CV >40%	17.5%	26.5%	1.69 (0.95–3.02)	0.080
Mean Hemoglobin <10 gm/dL	5.3%	9.0%	1.78 (0.68–4.65)	0.235
Any of the Above Five Outcomes	54.4%	77.3%	2.85 (1.72–4.70)	<0.001

^*All statistical comparisons were made using the chi square test

^**There were no acute rejection events in the non-AA group during year 4 so an odds-ratio between non-AAs and AAs could not be computed