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. Author manuscript; available in PMC: 2020 Jan 2.
Published in final edited form as: Virology. 2018 Oct 31;526:146–154. doi: 10.1016/j.virol.2018.10.014

Fig. 1.

Fig. 1.

Lung virus titers and lung cytokine/chemokine concentrations in four-week-old mice infected intranasally with EV-D68 and treated with guanidine. Mice (n = 12/group) were treated b.i.d. × 5 days beginning 4 h post-infection. Graphs represent the mean values and standard error of groups of four mice each. (A) Guanidine reduced lung virus titers in EV-D68-infected mice. (B) Blood virus titers were reduced by guanidine treatment at 100 and 200 mg/kg/day. (C) Increases in IL-6 in lung tissue induced by EV-D68 infection were prevented by guanidine treatment. (D) Guanidine decreased production of MCP-1 in the lungs caused by EV-D68 infection. *P < 0.05, ***P < 0.001, ****P < 0.0001.