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. Author manuscript; available in PMC: 2020 Jan 2.
Published in final edited form as: Virology. 2018 Oct 31;526:146–154. doi: 10.1016/j.virol.2018.10.014

Fig. 5. Survival and mean neurological scores for 10-day-old mice infected with EV-D68 and treated with guanidine.

Fig. 5.

Mice (n = 5/group) were treated b.i.d. × 5 days beginning 4 h post-infection. (A) Guanidine treatment significantly improved survival in 10-day-old mice infected via the i.p route with EV-D68. Lower doses of guanidine did not affect survival or mean day of death.(B) Treatment with guanidine prevented paralysis as measured by decreases in mean neurological scores. *P < 0.05, **P < 0.01.