Table 1: Distribution and severity of TDP-43 pathology in 84 TDP-43 positive cases.
| Brain regions | Frequency | Median Score |
The number of cases in each score |
|||||
|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | NA | ||||
| Midbrain tegmentum | 80% (66/83) | 1 (1, 3) | 17 | 26 | 15 | 25 | 1 | |
| Subthalamic nucleus | 69% (58/84) | 1 (0, 2) | 26 | 19 | 24 | 15 | 0 | |
| Pontine tegmentum | 65% (55/84) | 1 (0, 2) | 29 | 25 | 11 | 19 | 0 | |
| Substantia nigra | 63% (52/83) | 1 (0, 2) | 31 | 29 | 14 | 9 | 1 | |
| Posterior hypothalamus | 60% (50/84) | 1 (0, 2) | 34 | 25 | 14 | 11 | 0 | |
| Midbrain tectum | 58% (48/83) | 1 (0, 2) | 35 | 23 | 11 | 14 | 1 | |
| Medullary tegmentum | 56% (43/77) | 1 (0, 1) | 34 | 27 | 4 | 12 | 7 | |
| Locus coeruleus | 55% (44/80) | 1 (0, 1) | 36 | 26 | 14 | 4 | 4 | |
| Inferior olive | 51% (39/84) | 0 (0, 1) | 38 | 23 | 7 | 9 | 7 | |
| Anterior hypothalamus | 50% (41/82) | 0 (0, 2) | 41 | 11 | 16 | 14 | 2 | |
| Thalamus | 50% (42/84) | 0 (0, 1) | 42 | 27 | 8 | 7 | 0 | |
| Basal nucleus | 49% (41/84) | 0 (0, 1) | 43 | 22 | 11 | 8 | 0 | |
| Putamen | 46% (39/84) | 1 (0, 1) | 45 | 27 | 8 | 4 | 0 | |
| Globus pallidus | 46% (39/84) | 1 (0, 1) | 45 | 21 | 13 | 5 | 0 | |
| Amygdala | 43% (36/83) | 1 (0, 1) | 47 | 21 | 7 | 8 | 1 | |
| Superior frontal gyrus | 43% (35/82) | 0 (0, 1) | 47 | 23 | 7 | 5 | 2 | |
| Cingulate gyrus | 39% (32/82) | 0 (0, 1) | 50 | 21 | 7 | 4 | 2 | |
| Hippocampus | 35% (29/84) | 0 (0, 1) | 55 | 16 | 5 | 8 | 0 | |
| Pontine base | 30% (25/84) | 0 (0, 1) | 59 | 18 | 3 | 4 | 0 | |
| Precentral gyrus, grey | 29% (24/83) | 0 (0, 1) | 59 | 13 | 6 | 5 | 1 | |
| Entorhinal cortex | 24% (20/84) | 0 (0, 0) | 64 | 15 | 4 | 1 | 0 | |
| Dentate nucleus | 23% (19/81) | 0 (0, 0) | 62 | 15 | 3 | 1 | 3 | |
| Corpus callosum | 21% (17/81) | 0 (0, 0) | 64 | 11 | 3 | 3 | 3 | |
| Precentral gyrus, white | 19% (16/83) | 0 (0, 0) | 67 | 11 | 4 | 1 | 1 | |
| Cerebellar white matter | 15% (12/82) | 0 (0, 0) | 70 | 7 | 3 | 2 | 2 | |
| Dentate gyrus | 12% (10/84) | 0 (0, 0) | 74 | 8 | 1 | 1 | 0 | |
Values are % (n) and median (25th, 75th range). Denominators of frequency are the number of TDP-43 positive CBD cases, not total CBD cases. NA, not available.