Table 2: Cluster analyses by TDP-43 pathology and clinicopathologic associations.
| TDP-negative N = 103 |
TDP-limited N = 44 |
TDP-severe N = 40 |
P value | |
|---|---|---|---|---|
| Male, No. (%) | 54 (52%) | 21 (48%) | 15 (38%) | 0.284 |
| Age at death, years | 69 ± 8 | 70 ± 7 | 72 ± 9 | 0.226 |
| Brain weight, g | 1130 ± 130 | 1090 ± 160 | 1100 ± 160 | 0.337 |
| Thickness of corpus callosum, mm | 3.4 ± 1.1 | 3.4 ± 1.0 | 3.4 ± 1.0 | 0.987 |
| Braak neurofibrillary tangles stage | II (I, III) | II (I, III) | II (I, III) | 0.771 |
| Thal amyloid phase | 0 (0, 2) | 0 (0, 1) | 0 (0, 1) | 0.813 |
| Alzheimer disease | 7 (7%) | 2 (5%) | 2 (5%) | 0.919 |
| Hippocampal sclerosis | 0 (0%) | 1 (2%) | 1 (3%) | 0.200 |
| Argyrophilic grain disease | 41 (40%) | 21 (48%) | 25 (63%) | 0.046 |
| Lewy-related pathology | 5 (5%) | 2 (5%) | 5 (13%) | 0.234 |
| Clinical characteristics | ||||
| Disease duration, years | 6 ± 3 | 7 ± 2 | 7 ± 4 | 0.396 |
| Clinical diagnosis of CBS | 48/102 (47%) | 17/44 (39%) | 4/40 (10%) | 7.4×10−5 |
| Clinical diagnosis of PSP | 31/102 (30%) | 14/44 (32%) | 32/40 (80%) | 1.4×10−7 |
| Diagnostic physician type | 0.799 | |||
| Movement disorder specialist | 45/95 (47%) | 19/41 (46%) | 18/38 (47%) | |
| Dementia specialist | 10/95 (11%) | 7/41 (17%) | 3/38 (8%) | |
| General neurologist | 36/95 (38%) | 14/41 (34%) | 14/38 (37%) | |
| Non-neurologist | 4/95 (4%) | 1/421 (2%) | 3/38 (8%) | |
| Downward gaze palsy | 30/89 (34%) | 13/37 (35%) | 29/34 (85%) | 4.3×10−7 |
| Asymmetric rigidity/apraxia | 51/69 (74%) | 20/29 (69%) | 15/23 (65%) | 0.766 |
| Initial presentations | 0.231 | |||
| Motor symptoms | 48/84 (57%) | 17/35 (49%) | 12/29 (41%) | |
| Cognitive/behavioral symptoms | 20/84 (24%) | 14/35 (40%) | 9/29 (31%) | |
| Mixed | 16/84 (19%) | 4/35 (11%) | 8/29 (28%) |
Data are displayed as n (%), mean ± SD, and median (25th, 75th range).