Table 3: Clinicopathologic characteristics compared by clinical diagnoses.
CBS N = 69 |
PSP N = 77 |
AD N = 13 |
FTD N = 12 |
Others N = 15 |
P value | |
---|---|---|---|---|---|---|
Male, No. (%) | 31 (45%) | 39 (51%) | 3 (23%) | 7 (58%) | 9 (60%) | 0.285 |
Age at death, years | 71 ± 7 | 68 ± 8 | 75 ± 10* | 67 ± 7 | 72 ± 8 | 0.010 |
Disease duration, years | 7 ± 2 | 6 ± 3 | 7 ± 3 | 7 ± 2 | 5 ± 3 | 0.081 |
Diagnostic physician type | 6.8×10−8 | |||||
Movement disorder specialist | 40/65 (62%) | 35/71 (49%) | 0/13 (0%) | 1/12 (8%) | 6/13 (46%) | |
Dementia specialist | 6/65 (9%) | 4/71 (6%) | 2/13 (15%) | 5/12 (42%) | 3/13 (23%) | |
General neurologist | 18/65 (28%) | 31/71 (44%) | 8/13 (62%) | 6/12 (50%) | 1/13 (8%) | |
Non-neurologist | 1/65 (2%) | 1/71 (1%) | 3/13 (23%) | 0/12 (0%) | 3/13 (23%) | |
Asymmetric rigidity/apraxia | 57/61 (93%) | 23/41 (56%) | 0/4 (0%) | 3/9 (33%) | 3/7 (43%) | 8.1×10−9 |
Downward gaze palsy | 17/61 (28%) | 50/67 (83%) | 1/9 (11%) | 1/11 (9%) | 3/12 (25%) | 1.5×10−9 |
Initial presentations | 5.6×10−8 | |||||
Motor symptoms | 44/58 (76%) | 28/61 (46%) | 1/6 (17%) | 0/11 (0%) | 4/12 (33%) | |
Cognitive/behavioral symptoms |
5/58 (9%) | 17/61 (28%) | 5/6 (83%) | 10/11 (91%) | 6/12 (50%) | |
Mixed | 9/58 (16%) | 16/61 (26%) | 0/6 (0%) | 1/11 (9%) | 2/12 (17%) | |
Pathologic features | ||||||
Brain weight, g | 1100 ± 150 | 1140 ± 130 | 1000 ± 160* | 1020 ± 90* | 1170 ± 130 | 5.8×10−4 |
Thickness of corpus callosum, mm |
3.5 ± 1.0 | 3.6 ± 0.9 | 2.0 ± 0.7** | 2.1 ± 0.5** | 3.3 ± 1.2 | 3.2×10−7 |
TDP-43 pathology | 1.5×10−5 | |||||
TDP-limited | 17/69 (25%) | 14/77 (18%) | 4/13 (31%) | 5/12 (42%) | 4/15 (27%) | |
TDP-severe | 4/69 (6%) | 32/77 (42%) | 3/13 (23%) | 1/12 (8%) | 0/15 (0%) |
Data are displayed as n (%) and mean ± SD. “Others” are atypical Parkinson’s disease, Parkinson’s disease with dementia or dementia with Lewy bodies (N = 8), primary progressive aphasia (N = 5), and multiple system atrophy (N = 2).
indicates P value <0.05 compared to PSP;
indicates P value <0.05 compared to PSP and CBS.