Table 3: Clinicopathologic characteristics compared by clinical diagnoses.

	CBS N = 69	PSP N = 77	AD N = 13	FTD N = 12	Others N = 15	P value
Male, No. (%)	31 (45%)	39 (51%)	3 (23%)	7 (58%)	9 (60%)	0.285
Age at death, years	71 ± 7	68 ± 8	75 ± 10*	67 ± 7	72 ± 8	0.010
Disease duration, years	7 ± 2	6 ± 3	7 ± 3	7 ± 2	5 ± 3	0.081
Diagnostic physician type						6.8×10−8
Movement disorder specialist	40/65 (62%)	35/71 (49%)	0/13 (0%)	1/12 (8%)	6/13 (46%)
Dementia specialist	6/65 (9%)	4/71 (6%)	2/13 (15%)	5/12 (42%)	3/13 (23%)
General neurologist	18/65 (28%)	31/71 (44%)	8/13 (62%)	6/12 (50%)	1/13 (8%)
Non-neurologist	1/65 (2%)	1/71 (1%)	3/13 (23%)	0/12 (0%)	3/13 (23%)
Asymmetric rigidity/apraxia	57/61 (93%)	23/41 (56%)	0/4 (0%)	3/9 (33%)	3/7 (43%)	8.1×10−9
Downward gaze palsy	17/61 (28%)	50/67 (83%)	1/9 (11%)	1/11 (9%)	3/12 (25%)	1.5×10−9
Initial presentations						5.6×10−8
Motor symptoms	44/58 (76%)	28/61 (46%)	1/6 (17%)	0/11 (0%)	4/12 (33%)
Cognitive/behavioral symptoms	5/58 (9%)	17/61 (28%)	5/6 (83%)	10/11 (91%)	6/12 (50%)
Mixed	9/58 (16%)	16/61 (26%)	0/6 (0%)	1/11 (9%)	2/12 (17%)
Pathologic features
Brain weight, g	1100 ± 150	1140 ± 130	1000 ± 160*	1020 ± 90*	1170 ± 130	5.8×10−4
Thickness of corpus callosum, mm	3.5 ± 1.0	3.6 ± 0.9	2.0 ± 0.7**	2.1 ± 0.5**	3.3 ± 1.2	3.2×10−7
TDP-43 pathology						1.5×10−5
TDP-limited	17/69 (25%)	14/77 (18%)	4/13 (31%)	5/12 (42%)	4/15 (27%)
TDP-severe	4/69 (6%)	32/77 (42%)	3/13 (23%)	1/12 (8%)	0/15 (0%)

Data are displayed as n (%) and mean ± SD. “Others” are atypical Parkinson’s disease, Parkinson’s disease with dementia or dementia with Lewy bodies (N = 8), primary progressive aphasia (N = 5), and multiple system atrophy (N = 2).

^*indicates P value <0.05 compared to PSP;

^**indicates P value <0.05 compared to PSP and CBS.