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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Acta Neuropathol. 2018 Jun 20;136(3):389–404. doi: 10.1007/s00401-018-1878-z

Table 4: Multivariate logistic regression models.

Odds ratio 95% CI P value
Model 1 (DV: clinical diagnosis of PSP)
Age at death, years 0.99 0.92–1.05 0.651
Sex (0: female, 1: male) 1.01 0.35–2.88 0.990
Disease duration, years 0.95 0.80–1.12 0.523
Downward gaze palsy 26.9 8.39–86.3 3.1×10−8
Asymmetric rigidity/apraxia 0.27 0.08–0.87 0.028
Model 2 (DV: downward gaze palsy)
Age at death, years 1.02 0.97–1.08 0.385
Sex (0: female, 1: male) 1.04 0.44–2.46 0.928
Disease duration, years 0.88 0.73–1.06 0.181
TDP-43, midbrain tectum 9.77 1.75–54.7 0.010
TDP-43, midbrain tegmentum 0.79 0.31–2.02 0.618
Tau, oculomotor complex 1.51 1.09–2.08 0.012
Tau, midbrain tectum 0.79 0.59–1.06 0.120

TDP-43 and tau pathology are four-point scale (0: absent, 1: mild, 2: moderate, 3: severe). Abbreviation: DV, dependent variable; PSP, progressive supranuclear palsy.