. Author manuscript; available in PMC: 2019 Sep 1.

Published in final edited form as: Acta Neuropathol. 2018 Jun 20;136(3):389–404. doi: 10.1007/s00401-018-1878-z

Table 5: Genetic findings of TDP-43 positive CBD compared to CBD.

	TDP- Negative N = 103	TDP- Limited N = 44	TDP- Severe N = 40	Overall P	Negative vs Positive		Negative/Limited vs Severe
					P	OR (95% CI)	P	OR (95% CI)
GRN, T/T allele	6%	7%	14%	0.420	0.409	1.67 (0.48–6.14)	0.184	2.18 (0.53–7.84)
TMEM106B, G/G allele	12%	15%	11%	0.861	0.820	1.11 (0.40–3.07)	1.000	0.84 (0.19–2.82)
MAPT, H1/H1	91%	89%	65%	0.002	0.021	0.36 (0.13–0.91)	5.36×10⁻⁴	0.21 (0.08–0.55)
APOE, E4	38%	26%	32%	0.351	0.205	0.66 (0.33–1.29)	1.000	0.92 (0.39–2.10)

GRN (SNP rs5848 C/T SNPs, T minor allele), TMEM106B (rs3173615 C/G SNPs, C minor allele).