Table 5: Genetic findings of TDP-43 positive CBD compared to CBD.
TDP- Negative N = 103 |
TDP- Limited N = 44 |
TDP- Severe N = 40 |
Overall P |
Negative vs Positive |
Negative/Limited vs Severe |
|||
---|---|---|---|---|---|---|---|---|
P | OR (95% CI) | P | OR (95% CI) | |||||
GRN, T/T allele | 6% | 7% | 14% | 0.420 | 0.409 | 1.67 (0.48–6.14) | 0.184 | 2.18 (0.53–7.84) |
TMEM106B, G/G allele | 12% | 15% | 11% | 0.861 | 0.820 | 1.11 (0.40–3.07) | 1.000 | 0.84 (0.19–2.82) |
MAPT, H1/H1 | 91% | 89% | 65% | 0.002 | 0.021 | 0.36 (0.13–0.91) | 5.36×10−4 | 0.21 (0.08–0.55) |
APOE, E4 | 38% | 26% | 32% | 0.351 | 0.205 | 0.66 (0.33–1.29) | 1.000 | 0.92 (0.39–2.10) |
GRN (SNP rs5848 C/T SNPs, T minor allele), TMEM106B (rs3173615 C/G SNPs, C minor allele).