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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: J Mol Evol. 2018 Nov 3;86(9):613–617. doi: 10.1007/s00239-018-9873-5

Figure 1. Alignment of the Human and Non-Functional Guinea Pig ZnT8 Peptide Sequences.

Figure 1.

Figure 1.

The alignment of the peptide sequence of human ZnT8 (Accession Number NM_173851) with the non-functional Guinea pig ZnT8 is shown. Identities are indicated by matching letters and similarities by the ‘+’ symbol. The two stop codons (X) in the Guinea pig peptide sequence are shown in red. An 11 bp deletion in the putative Guinea pig exon 7 deletes 3 amino acids (indicated by ZZZ in blue) and creates a frameshift mutation. If translated, the open reading frame would be maintained 3 ‘ of this frameshift as shown. Putative transmembrane domains predicted using TOPCONS web server (Tsirigos et al. 2015) are shaded in gray. The locations of the 6 transmembrane domains are somewhat different to those previously predicted (Chimienti et al. 2004).