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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Shock. 2019 Jun;51(6):731–739. doi: 10.1097/SHK.0000000000001203

FIG. 2. Effect of cancer and sepsis on splenocyte T cell number, apoptosis and activation.

FIG. 2

Cancer septic mice had an increase in the absolute number of CD4+ T cells 24 hours after CLP compared to previously healthy mice (A, p=0.0006) associated with decreased Annexin+7AAD+ CD4+ apoptotic cells (B, p=0.0006). This was not associated with a change in activation as measured by the percentage of CD25+ CD4+ (C, p=0.10) or CD69+ CD4+ cells (D, p=0.87). Cancer septic mice also had an increase in the absolute number of CD8+ T cells (E, p=0.002) without a statistically significant change in Annexin+7AAD+ CD8+ apoptotic cells (F, p=0.31). Activation was decreased in CD8+ cells in cancer septic mice as measured by the percentage of CD25+ (G, p=0.0006) or CD69+ cells (H, p=0.05), n=7 for all groups except n=6 for cancer septic CD69.