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Inhibition of gyrase catalyzed reactions by GSK000 and moxifloxacin. The effects of GSK000 (left panels) and moxifloxacin (right panels) on the supercoiling of relaxed DNA (top panels) and the relaxation of positively supercoiled DNA (bottom panels) are shown. The positions of relaxed (Rel), negatively supercoiled [(−)SC], and positively supercoiled [(+)SC] DNA are indicated. Gels are representative of at least four independent experiments.
