Figure 5.

An increase in mean degree (a) and number of vertices per component (c) suggests increased connectivity and β-cell cluster size between 1–35 weeks and 12–24 months. Mean degree (a), number of components perislet (b) and number of vertices per component (c) are given for all (red), large (blue) and small (green) islets for each developmental stage. Component results are shown for S + NS (solid lines) and NS only (dashed lines). * indicates a statistically significant difference using the Mann-Whitney test and a Bonferroni correction (N = 27 (a) and N = 54 (b) and (c)). The standard deviation for each data point is given in tables S1–S3.