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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Immunohorizons. 2018 Jan 1;2(1):54–66. doi: 10.4049/immunohorizons.1700069

FIGURE 4. PD-1 deficiency promotes the development of splenic GCs in male mice, and MR1 dissolves GCs in both genders.

FIGURE 4

Frozen sections of spleens from 4–5-mo-old WT (n = 4) and PD-1−/− NOD.H-2h4 mice (n = 4 females, n = 8 males) were stained for expression of B cells (IgM, red; PNA, green). Original magnification ×100. Results are expressed as the number of GCs per follicle. (A) Untreated versus WT NOD.H-2h4 mice. *p < 0.05. (B) PD-1−/− mice given MR1 or isotype control (n = 5 females, n = 4 males). (B) **p < 0.001, ***p < 0.0001.