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. Author manuscript; available in PMC: 2019 Apr 3.
Published in final edited form as: Nature. 2018 Oct 3;562(7727):444–447. doi: 10.1038/s41586-018-0587-z

Figure 3. The FimD N-tail adopts three conformations during a subunit-incorporation cycle.

Figure 3.

(a) Modeled Conformer 3 in which FimA (wheat) bound to a FimC’ chaperone (yellow) is being recruited by the FimD-tip complex. In the recruitment phase, the FimD N-tail is folded as a helical motif. (b) Comparison of FimD NTD and N-tail in Conformers 1 and 3 by superimposing the FimD β-barrel. (c) A 3-step NTD-to-CTDs handover mechanism of FimC-subunit at the usher, highlighting the three conformations of the FimD N-tail: disordered in Step 1, helical in Step 2, and a loop in Step 3. See text for details.