Table 3.

Surgical uterine evacuation by trial characteristics in groups treated with 800 mcg misoprostol vaginally

	Trial groups N=31	Evaluable women N=10010	Women who had surgical uterine evacuation N=1895		ORa
			N	%	OR	95% CI
Number of treated women per group
3–100	15	823	193	23%	1
101–500	11	2098	209	10%	0.36	0.21	0.61
501–720	3	1745	242	14%	0.53	0.30	0.93
2805, 3225	2	5344	1251	23%	1.00	0.62	1.60
Lost to follow-up in group
0	22	2991	390	13%	1
>0 to 10%	7	1675	254	15%	1.19	0.81	1.75
>10%	2	5344	1251	23%	2.04	1.56	2.66
Publication date
1994–1999	8	1342	164	12%	1
2000–2004	12	4704	859	18%	1.60	0.91	2.82
2005-present	11	3964	872	22%	2.03	1.39	2.96
Study design
randomized	12	1602	311	19%	1
prospective cohort or case series	15	2603	284	11%	0.51	0.35	0.74
retrospective cohort or case series	4	5805	1300	22%	1.20	0.82	1.74
Region
North America	6	841	95	11%	1
Asia	12	668	157	24%	1.97	1.25	3.11
Latin or South America	8	7102	1426	20%	2.41	1.16	5.03
other or multiple	5	1399	217	16%	1.44	0.95	2.20
Planned maximum gestational age
42–56 days	14	3905	743	19%	1
57–63 days	11	2742	380	14%	0.68	0.43	1.09
≥63 days	6	3363	772	23%	1.27	0.85	1.89
Misoprostol moistened before vaginal administration
no or not stated	11	6093	1419	23%	1
yes	20	3917	476	12%	0.46	0.35	0.60
Total number of allowed doses
1	4	305	78	26%	1
2	8	2862	656	23%	0.87	0.47	1.60
3	16	6221	1106	18%	0.63	0.30	1.31
4+	3	622	55	9%	0.28	0.14	0.57
Maximum duration of dosing if all allowed contingent doses were taken
0 (only 1 dose allowed)	4	305	78	26%	1
1–24h	9	3759	817	22%	0.81	0.42	1.54
25–48h	9	5138	910	18%	0.63	0.29	1.37
>48 h	9	808	90	11%	0.36	0.16	0.82
Protocol permitted patient to take misoprostol at home
all or some	13	8558	1663	19%	1
none	18	1452	232	16%	0.79	0.49	1.26
Evaluated by ultrasound prior to decision to perform surgery
all patients	29	8985	1729	19%	1
some or no patients	2	1025	166	16%	0.81	0.62	1.06
Earliest timing of decision re. surgery
≤72h	10	4403	893	20%	1
73h-7d	8	1087	133	12%	0.55	0.31	0.96
>7d	13	4520	869	19%	0.94	0.59	1.49

^aConfidence intervals are adjusted for clustering by paper.