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. Author manuscript; available in PMC: 2019 Dec 25.

Published in final edited form as: J Am Coll Cardiol. 2018 Dec 25;72(25):3233–3242. doi: 10.1016/j.jacc.2018.09.051

Table 3:

NNT to prevent first occurrence of MACE through 10 years

CAC Score	Therapy	N	MACE	CIF^*	ARR	NNT (NNH)	aSHR^†	p value
0	No Statin	5618	114	0.0295	(0.03%)	(3571)	1.01	0.94
0	Statin	3742	100	0.0298	(0.03%)	(3571)	1.01	0.94
1–100	No Statin	944	32	0.0401	1.00%	100	0.75	0.095
1–100	Statin	1933	76	0.0301	1.00%	100	0.75	0.095
101+	No Statin	196	32	0.1409	8.53%	12	0.38	<0.0001
101+	Statin	1211	123	0.0556	8.53%	12	0.38	<0.0001

CIF – Cumulative incidence function. ARR – Absolute Risk Reduction. NNT – Number needed to treat. NNH – Number needed to harm. aSHR – adjusted subhazard ratio. MACE – Major adverse cardiovascular event. CAC – Coronary artery calcium.

^*

Cumulative incidence of MACE at 10 years, calculated at observed marginal differences for covariates (means).

^†

aSHR calculated at 10 years.