Table 1.

Examples of large-scale GWAS and GWAS meta-analyses for BMD illustrates the increase in identified loci as a function of sample size.

Study	Phenotype	Sample size	Association count
Morris et al. (2018)[19]	Estimated heel BMD	426,824	1103 independent associations (518 loci, 301 novel)
Kemp et al. (2017)[17]	Estimated heel BMD	142,487	307 independent associations (203 loci, 153 novel)
Estrada et al. (2012) (meta-analysis) [16]	Lumbar spine and femoral neck BMD	83,894 (32,961 discovery, 50,933 replication)	64 independent associations (56 loci, 32 novel)
Rivadeneira et al. (2009) [40]	Lumbar spine and femoral neck BMD	19,195	20 independent associations (20 loci, 13 novel)

Note that the most recent discovery of 518 loci encompassed nearly all of the previously discovered loci identified in prior studies.