Table 2:
Sero-positivity to H pylori proteins and CRC risk, among all and by race/ethnicity.
| All | White | African American | Asian American | Latino | Other/unknown/multiracial | |
|---|---|---|---|---|---|---|
| N, cases/controls | 4063 / 4063 | 3067 / 3067 | 399 / 399 | 307 / 307 | 211 / 211 | 79 / 79 |
| N (%) H pylori+1 | 1682 (41) / 1606 (40) | 1067 (35) / 1027 (33) | 282 (71) / 259 (65) | 140 (46) / 121 (39) | 156 (74) / 163 (77) | 37 (47) / 36 (46) |
| OR (95% CI)2 | 1.09 (0.99-1.20) | 1.06 (0.95-1.18) | 1.30 (0.97-1.76) | 1.30 (0.94-1.81) | 0.84 (0.55-1.30) | 1.05 (0.57-1.94) |
| N (%) H pylori+1 VacA+ | 1434 (35) / 1350 (33) | 876 (29) / 830 (27) | 267 (67) / 233 (58) | 123 (40) / 111 (36) | 134 (64) / 145 (69) | 34 (43) / 31 (39) |
| OR (95% CI)2 | 1.11 (1.01-1.22) | 1.08 (0.96-1.21) | 1.45 (1.08-1.95) | 1.20 (0.85-1.69) | 0.80 (0.53-1.19) | 1.18 (0.62-2.25) |
| N (%) H pylori+1 GroEL+ | 1557 (38) / 1467 (36) | 996 (32) / 957 (31) | 268 (67) / 239 (60) | 114 (37) / 96 (31) | 146 (69) / 143 (68) | 33 (42) / 32 (41) |
| OR (95% CI)2 | 1.11 (1.01-1.22) | 1.06 (0.95-1.19) | 1.39 (1.03-1.87) | 1.32 (0.93-1.87) | 1.07 (0.70-1.64) | 1.06 (0.55-2.01) |
| N (%) H pylori+1 Omp+ | 1400 (34) / 1316 (32) | 870 (28) / 812 (26) | 255 (64) / 240 (60) | 116 (38) / 100 (33) | 127 (60) / 137 (65) | 32 (41) / 27 (34) |
| OR (95% CI)2 | 1.11 (1.01-1.22) | 1.10 (0.98-1.24) | 1.18 (0.88-1.57) | 1.26 (0.90-1.76) | 0.83 (0.56-1.21) | 1.31 (0.69-2.52) |
| N (%) H pylori+1 HcpC+ | 1407 (35) / 1325 (33) | 880 (29) / 847 (28) | 250 (63) / 223 (56) | 114 (37) / 98 (32) | 127 (60) / 128 (61) | 36 (46) / 29 (37) |
| OR (95% CI)2 | 1.10 (1.00-1.22) | 1.06 (0.94-1.19) | 1.33 (1.00-1.77) | 1.27 (0.90-1.79) | 0.98 (0.68-1.43) | 1.39 (0.76-2.55) |
| N (%) H pylori+1 CagA+ | 1139 (28) / 1074 (26) | 645 (21) / 609 (20) | 244 (61) / 221 (55) | 115 (37) / 95 (31) | 104 (49) / 120 (57) | 31 (39) / 29 (37) |
| OR (95% CI)2 | 1.10 (0.99-1.22) | 1.08 (0.95-1.23) | 1.28 (0.96-1.70) | 1.39 (0.97-1.98) | 0.72 (0.49-1.08) | 1.12 (0.58-2.15) |
| N (%) H pylori+1 HP0231+ | 782 (19) / 729 (18) | 552 (18) / 509 (17) | 126 (32) / 105 (26) | 41 (13) / 36 (12) | 51 (24) / 62 (29) | 12 (15) / 17 (22) |
| OR (95% CI)2 | 1.09 (0.98-1.22) | 1.10 (0.97-1.26) | 1.27 (0.94-1.70) | 1.17 (0.71-1.92) | 0.78 (0.51-1.19) | 0.67 (0.30-1.48) |
| N (%) H pylori+1 HP0305+ | 886 (22) / 870 (21) | 565 (18) / 541 (18) | 163 (41) / 161 (40) | 64 (21) / 58 (19) | 73 (35) / 91 (43) | 21 (27) / 19 (24) |
| OR (95% CI)2 | 1.03 (0.92-1.15) | 1.06 (0.93-1.21) | 1.02 (0.77-1.36) | 1.14 (0.76-1.72) | 0.71 (0.48-1.04) | 1.17 (0.54-2.52) |
| N (%) H pylori+1 UreA+ | 883 (22) / 869 (21) | 574 (19) / 577 (19) | 130 (33) / 133 (33) | 74 (24) / 61 (20) | 90 (43) / 78 (37) | 15 (19) / 20 (25) |
| OR (95% CI)2 | 1.02 (0.92-1.14) | 0.99 (0.87-1.13) | 0.97 (0.72-1.29) | 1.28 (0.87-1.89) | 1.27 (0.86-1.89) | 0.74 (0.37-1.47) |
| N (%) H pylori+1 HyuA+ | 802 (20) / 789 (19) | 530 (17) / 533 (17) | 112 (28) / 108 (27) | 57 (19) / 58 (19) | 85 (40) / 74 (35) | 18 (23) / 16 (20) |
| OR (95% CI)2 | 1.02 (0.91-1.14) | 0.99 (0.87-1.14) | 1.06 (0.77-1.46) | 0.98 (0.66-1.46) | 1.26 (0.84-1.88) | 1.15 (0.55-2.43) |
| N (%) H pylori+1 Cad+ | 593 (15) / 582 (14) | 386 (13) / 380 (12) | 119 (30) / 110 (28) | 23 (7) / 29 (9) | 55 (26) / 55 (26) | 10 (13) / 8 (10) |
| OR (95% CI)2 | 1.02 (0.90-1.16) | 1.02 (0.88-1.19) | 1.13 (0.82-1.55) | 0.77 (0.43-1.38) | 1.00 (0.64-1.57) | 1.25 (0.49-3.17) |
| N (%) H pylori+1 Catalase+ | 905 (22) / 910 (22) | 604 (20) / 603 (20) | 145 (36) / 142 (36) | 52 (17) / 59 (19) | 86 (41) / 88 (42) | 18 (23) / 18 (23) |
| OR (95% CI)2 | 0.99 (0.89-1.10) | 1.00 (0.88-1.14) | 1.03 (0.77-1.39) | 0.85 (0.56-1.30) | 0.96 (0.65-1.42) | 1.00 (0.48-2.10) |
| N (%) H pylori+1 HpaA+ | 628 (15) / 638 (16) | 374 (12) / 383 (12) | 140 (35) / 136 (34) | 47 (15) / 45 (15) | 55 (26) / 61 (29) | 12 (15) / 13 (16) |
| OR (95% CI)2 | 0.98 (0.87-1.11) | 0.97 (0.83-1.13) | 1.05 (0.78-1.40) | 1.05 (0.68-1.63) | 0.87 (0.57-1.33) | 0.91 (0.69-2.14) |
| N (%) H pylori+1 NapA+ | 785 (19) / 810 (20) | 501 (16) / 552 (18) | 122 (31) / 115 (30) | 55 (18) / 41 (13) | 89 (42) / 87 (41) | 18 (23) / 15 (19) |
| OR (95% CI)2 | 0.96 (0.86-1.07) | 0.89 (0.78-1.02) | 1.09 (0.80-1.47) | 1.39 (0.91-2.13) | 1.04 (0.70-1.56) | 1.25 (0.59-2.67) |
1
overall H pylori positive (≥4 antigens positive)
2
Conditional logistic regression model, controls are matched to cases by age, sex and race/ethnicity; significant associations at p<0.05 are marked in bold font