Figure 3:

An illustration on how PheWAS data can help with drug development/repurposing. Left side shows that if Drug X is effective in treating Disease A, Drug X may be repurposed to treat Disease B if both Disease A and Disease B share a common genetic etiology as evident by pleiotropy. Right side shows that if Drug Y inhibits a gene product and a loss-of-function variant in a gene decreases risk for Disease C, then Drug Y may be used to treat Disease C. If the same functional variant increases risk for Disease D, Disease D may be an adverse event when treating with Drug Y.