Figure 5:

A simplified illustration of the historical and future progression of human genomic research starting with small family-based studies (e.g., linkage studies) to ever larger studies of unrelated individuals (e.g., GWAS, PheWAS, and GWAS-by-PheWAS). As sample size (purple) becomes exceptionally large, future studies may include population-based family studies to identify increasing number of trait associated variants (pink).