TBI Model	Species	Treatment Paradigm	Outcomes	Reference
FPI	Rat	Twice daily 10 mg/kg P7C3–A20 IP 30 min post TBI for 7 days	Decreased contusion volume; protected pericontusional mature neurons; augmented adult hippocampal neurogenesis; improved neurobehavioral outcomes	Blaya et al., 2014
FPI	Rat	Twice daily 10 mg/kg P7C3–A20 IP 30 min or 3 hr post TBI for 7 days	Preserved injury-induced reduction in LTP	Unpublished
CCI	Mouse	Twice daily 10 mg/kg P7C3–A20 IP 30 min post TBI for 7 days	Increased early-stage adult hippocampal neurogenesis	Unpublished
Blast	Mouse	3, 10, and 30 mg/kg/day P7C3–S243 IP or oral 24 hrs post TBI for 11 days	Blocked axonal degeneration in brain; improved learning, memory, motor coordination; preserved synaptic plasticity	Yin et al, 2014
FPI	Rat	Twice daily 10 mg/kg P7C3–A20 IP 30 min post TBI for 7 days	Reduced reactive phenotype of activated microglia, macrophages, astrocytes (qualitative)	Unpublished