Figure 4.

Putative role of infection associated shifts in microbial community post-infection IBS. A host with Clostridiales predominant microbiota type is likely to remain in eubiosis state following infection, whereas, presence of Bacteroidetes predominant community may predispose to development of long-term dysbiosis upon infection. Dysbiosis can then result in shifts in bile acid composition, cytokine and immune milieu which can affect epithelial and neuromuscular function and further perpetuate dysbiosis.