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. Author manuscript; available in PMC: 2019 Dec 20.
Published in final edited form as: Cell Chem Biol. 2018 Oct 11;25(12):1506–1518.e13. doi: 10.1016/j.chembiol.2018.09.010

Figure 1– Determination of specific protein binding to tetracyclines.

Figure 1–

(A) Represented structures of immobilized Col-3 and doxycycline affinity matrices (B) Scheme for tetracycline target identification with affinity isolation and tandem MS-based SILAC proteomics. (C) A STRING network map of the specifically bound proteins (FDR < 0.05) that were identified in both the Col-3 and doxycycline affinity matrix pulldowns. All proteins identified map to the human 80S ribosome or its closely associated factors. See also Figure S1 and S2.