Skip to main content
. Author manuscript; available in PMC: 2019 Dec 20.
Published in final edited form as: Cell Chem Biol. 2018 Oct 11;25(12):1506–1518.e13. doi: 10.1016/j.chembiol.2018.09.010

Figure 3. Modeled structural representations of putative binding sites for the tetracyclines Col-3 and doxycycline.

Figure 3.

Modeled human ribosomal sites showing potential rRNA binding pockets for Col-3 and doxycycline on the small, 40S subunit at (A) h16 and (B) h18. Modeled sites showing potential rRNA binding pockets for Col-3 and doxycycline on the large, 60S subunit at (C) H89 (D) peptidyl exit tunnel (PET). Crosslinked bases are highlighted in magenta and magenta spheres represent potential binding pockets for Col-3 and doxycycline at each site. Small green spheres represent divalent magnesium ions.