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. Author manuscript; available in PMC: 2018 Dec 28.
Published in final edited form as: Science. 2014 Feb 20;343(6176):1221–1228. doi: 10.1126/science.1243462

Fig. 1. Degradation of cccDNA in IFN-α treated HepaRG cells and primary human hepatocytes.

Fig. 1.

(A, B, C, E, and F) HBV-infected dHepaRG were treated with IFN-α at day 10 post-infection (dpi). Different regimens of treatment were applied as indicated. (D) HBVinfected primary human hepatocyte (PHH) were treated with IFN-α at dpi 3 for 13 days. Levels of HBeAg, total intracellular DNA and cccDNA are given relative to mock treated cells. LAM: lamivudine; ETV: entecavir. Mean values +/− standard deviation of replicates from independent experiments are given; data were analyzed by t test. * p < 0.05, ** p < 0.01 and *** p < 0.001.