Table 2.
Genotype and allele frequency distribution of CYP3A5*3, COQ and SLCO1B1 in myopathy and tolerant group.
| Gene (rs number) | Genotype and allele | Myopathy, n = 38 | Tolerant, n = 164 | OR | CI at 95% | P value |
|---|---|---|---|---|---|---|
| CYP3A5*3 (rs776746) | TT | 4 (10.53) | 21 (12.80) | |||
| TC | 14 (36.84) | 87 (53.05) | 1.24 | 0.40–3.87 | 0.79 | |
| CC | 20 (52.63) | 56 (34.15) | 2.14 | 1.04–4.37 | 0.04* | |
| T | 22 (28.95) | 129 (39.33) | ||||
| C | 54 (71.05) | 199 (60.67) | 1.59 | 0.92–2.73 | 0.11 | |
| COQ (rs4693075) | GG | 2 (5.26) | 14 (8.54) | |||
| GC | 16 (42.11) | 63 (38.41) | 1.68 | 0.36–7.72 | 0.54 | |
| CC | 20 (52.63) | 87 (53.05) | 0.98 | 0.48–1.99 | 1 | |
| G | 20 (26.32) | 91 (27.74) | ||||
| C | 56 (73.68) | 237 (72.26) | 1.07 | 0.61–1.89 | 0.88 | |
| SLCO1B1 (rs4149056) | TT | 35 (92.10) | 154 (93.90) | |||
| TC | 3 (7.89) | 10 (6.09) | 1.32 | 0.34–5.04 | 0.71 | |
| CC | 0 (0) | 0 (0) | ||||
| T | 73 (96.55) | 318 (96.95) | 1.30 | 0.35–4.86 | 0.71 | |
| C | 3 (3.44) | 10 (6.09) |
OR, odds ratio; CI, class interval. *P value less than 0.05 is considered as significant.