Table 1.

Pharmacokinetics of resveratrol (RVT) and benzo(a)pyrene (BaP; alone and in the presence of RVT) orally administered to Apc^Min/+ male mice.

Parameter	RVT	BaP	BaP + RVT
Area under curve (AUC; mg x h/ml)	0.10 ± 0.01	0.12 ± 0.005	0.07 ± 0.005
Biological half-life (t1/2; hrs)	1.0 ± 0.011	1.8 ± 0.018	0.85 ± 0.010*
Volume of distribution (Vd; ml/kg)	0.44 ± 0.050	0.58 ± 0.045	0.22 ± 0.064
Clearance (Cl; ml/hr/kg)	0.08 ± 0.006	0.10 ± 0.01	0.05 ± 0.004*
Mean residence time (MRT; hrs)	1.6 ± 0.018	2.4 ± 0.010	1.2± 0.004*
Elimination rate (Kd; hrs)	0.18 ± 0.03	0.17 ± 0.06	0.23 ± 0.004

Values represent mean ± standard error (n = 10). Asterisks denote statistical significance (p < 0.05) of toxicokinetic parameter values for BaP and RVT administered together compared to BaP alone administration.