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. Author manuscript; available in PMC: 2019 Jun 17.
Published in final edited form as: Nat Genet. 2018 Dec 17;51(1):106–116. doi: 10.1038/s41588-018-0288-4

Figure 4: Estimation of gene discovery rates in future cohorts.

Figure 4:

We estimate the number of genes reaching significance under the CH model at varying population sizes subsampled from the total cohort of 10,927 individuals. Both the number of significant genes with recurrent LGD and MIS30 DNMs appear to be saturating with limited new gene discovery as sample sizes grow. De novo missense variants (including MIS30), however, as a more general class demonstrate a more complex growth pattern with no best-fit line and, thus, likely represent the most important reservoir for new gene discovery as sequence data are generated from additional ASD and DD cohorts.