Figure 3.
Effects of acute social defeat stress and dominance status on the relative quantification of CRH mRNA expression. (A) In the BLA/CeA, dominants (DOM, n = 8) had a significantly greater expression of CRH mRNA compared to subordinates (SUB, n = 9) and no defeat controls (ND, n = 8), social status controls (SSC, n = 8) were significantly greater than subordinates and handled controls, while dominants and social status controls did not differ. (B) In the anterior BNST, no significant differences were found, although the pattern was similar to the BLA/CeA data, albeit with greater variability (DOM, n = 7; SUB, n = 8; SSC, n = 7; ND, n =6). (C) No significant differences were observed in the PVN (DOM, n =8; SUB, n = 8; SSC, n = 9; ND, n = 7). Data are shown as mean ± SEM. An asterisk indicates a significant difference between groups as determined by a Dunn’s test (*p <.05).