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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Mol Divers. 2018 Jun 22;22(4):893–906. doi: 10.1007/s11030-018-9839-y

SCHEME 1.

SCHEME 1

Synthesis of compounds 5d–7j.

Reagents and conditions: (a) Piperidine, room temperature; (b) Piperidine, Hydroxybenzaldehyde, ethanol, reflux; (c) Cl(CH2)2NR/Br(CH2)2R, K2CO3, NaI, DMF, 56 °C.