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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Mol Divers. 2018 Jun 22;22(4):893–906. doi: 10.1007/s11030-018-9839-y

TABLE 1.

Effects of new synthesized compounds on AChE and BChE

Compounds Position R IC50a (μmol/L)
Selectivity for AChEb
AChE BChE
5d Para graphic file with name nihms975658t1.jpg 0.37 ± 0.03 >500 >1340
6d Meta 0.92 ± 0.07 15.32 ± 1.16 16.64
7d Ortho 16.40 ± 0.22 15.16 ± 0.60 0.92
9d Para 18.61±1.06 >500 >26.86
10d Meta >500 44.02±2.37 <0.09
11d Ortho >500 >500 -
12k Para 1.65±0.09 8.48±0.29 5.15
13k Para 7.07 ± 0.46 13.22 ± 0.32 1.87
5e Para graphic file with name nihms975658t2.jpg 0.15 ± 0.01 4.11 ± 0.16 27.40
6e Meta 3.25 ± 0.14 4.62 ±0.16 1.42
7e Ortho 230.34±14.82 3.76±0.35 0.02
9e Para >500 >500 -
10e Meta >500 >500 -
11e Ortho >500 >500 -
12l Para 1.67±0.04 0.46±0.01 0.28
13l Para 28.95 ± 1.68 13.61 ± 0.53 0.47
5f Para graphic file with name nihms975658t3.jpg 0.69 ± 0.06 1.03 ± 0.05 1.49
6f Meta 0.61 ± 0.02 4.01 ± 0.14 6.61
7f Ortho 29.86 ± 0.98 4.50 ± 0.22 0.15
9f Para >500 >500 -
10f Meta 152.49±12.82 222.84±11.54 1.46
11f Ortho >500 106.14±3.09 0.21
12m Para 0.37±0.02 0.52±0.01 1.41
13m Para 9.58 ± 0.80 6.41 ± 0.36 0.67
5g Para graphic file with name nihms975658t4.jpg 4.34 ± 0.29 6.21 ±0.19 1.43
6g Meta 51.30 ± 1.04 1.12 ± 0.11 0.02
7g Ortho 202.70 ± 2.50 1.96 ± 0.14 0.01
5h Para graphic file with name nihms975658t5.jpg >500 >500 -
6h Meta >500 >500 -
7h Ortho 260.95±4.17 28.98±1.23 0.11
5i Para graphic file with name nihms975658t6.jpg >500 >500 -
6i Meta >500 >500 -
7i Ortho >500 >500 -
5j Para graphic file with name nihms975658t7.jpg >500 >500 -
6j Meta >500 >500 -
7j Ortho >500 100.33±6.84 <0.20
Rivastigmine* 10.54±0.86 0.26±0.08 0.02
a

IC50: 50% inhibitory concentration (means±SD of three assays).

b

Selectivity for AChE is defined as IC50 (BChE)/IC50 (AChE).

*

Used for control.