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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Ophthalmology. 2018 Oct 21;126(1):38–48. doi: 10.1016/j.ophtha.2018.10.031

Figure 4. Test of Genetic Risk Scores by Receiver Operating Characteristics.

Figure 4.

Genetic risk scores are described were created by adding allele counts across selected SNPs for each subject; a SNP with a negative estimate (beta) was recoded to the other allele so that genotype counts would be additive for POAG risk. SNPs for Genetic Risk Score #1 were the 11 significantly associated SNPs in Table 1 (B, blue line). SNPs for Genetic Risk Score #2 were 50 SNPs selected using a penalized logistic regression and cross-validation procedure (B, green line). SNPs for Genetic Risk Score #3 were 400 SNPs selected by the same penalized logistic regression and cross-validation procedure (B, red line). For comparison, AUC=0.5 is the dotted black line, and AUC from all ~12,900 SNPs is the solid black line. CTRL, controls; POAG, cases.