Fig. 4. Spatial extent and phenotypic correlates of molecular systems in expression and methylation.

(a) Comparison of extent of voxel correlations of neuropathologies and a coexpression modules (m109) at an uncorrected p < .01 threshold (solid bars) and a more stringent FDR = 5% threshold (hollow bars). Neuropathology measures are controlled for m109 and m109 is controlled for neuropathologies. b Brain regions associated with neuropathologies and m109. Color-coding matches panel 4A, with AD pathology in dark blue, global infarcts in green, coexpression m109 in red. c Comparison of extent of voxel correlations of neuropathologies and comethylation modules at uncorrected p < .01 threshold (solid bars) and more stringent FDR = 5% threshold (hollow bars). In this comparison, neuropathology measures are controlled for comethylation modules and modules are controlled for neuropathologies. d Brain regions associated with neuropathologies and comethylation modules. Color-coding matches panel 4C, with AD pathology in dark blue, global infarcts in green, comethylation m33 in pink and comethylation m66 in yellow. The distribution and extent of pathology appears to shift between 4B and 4D due to different number of subjects, and different covariates (expression vs methylation) included in model