Table 1.
Clinical characteristics of imaging omics cohort. Full classification criteria shown in supplementary data, and raw data available to download through www.radc.rush.edu
| w/ RNAseq | w/ DNA methylation | |
|---|---|---|
| n | 168 | 222 |
| age at death (mean, sd) | 89.74 (6.10) | 89.75 (5.96) |
| female (n, %) | 114 (67.9) | 153 (68.9) |
| years of education (mean, sd) | 15.92 (3.52) | 15.77 (3.59) |
| MMSE, last visit (mean, sd) | 20.54 (9.35) | 19.50 (9.68) |
| Clinical dementia (n, %) | 75 (44.6) | 112 (50.5) |
| MCI (n, %) | 44 (26.2) | 50 (22.5) |
| NCI (n, %) | 49 (29.2) | 60 (27.0) |
| AD (n, %) | 70 (41.7) | 106 (47.7) |
| Global AD pathology (mean, sd) | 0.69 (0.60) | 0.75 (0.62) |
| Amyloid score (mean, sd) | 4.62 (4.45) | 4.82 (4.52) |
| Tangles score (mean, sd) | 6.43 (8.45) | 6.89 (8.18) |
| Presence of gross infarctions (n, %) | 53 (31.5) | 72 (32.4) |
| Presence of microinfarcts (n, %) | 46 (27.4) | 57 (25.7) |
| Presence of Lewy bodies (n, %) | 30 (17.9) | 45 (20.3) |