Table 1:
Simulated Data parameters vs. NEPTUNE and C-PROBE Data Parameters
| eGFR Variability, SD or RMSE** | Percent Missing eGFR Follow-up Values | Correlation Between Successive eGFR Values* | |
|---|---|---|---|
| Simulated Data | 3, 5, 7, 9 | 0, 10, 20, 40, 60, 80 | 0, 0.2, 0.4, 0.6, 0.8 |
| NEPTUNE | 8.4 (4.3 – 13.6) | 10 (0 – 25) | 0.79 |
| MN | 8.7 (5.1 – 12.0) | 0 (0 – 20) | 0.80 |
| MCD | 11.3 (6.1 – 17.4) | 14 (0 – 33) | 0.56 |
| FSGS | 7.5 (4.0 – 13.7) | 10 (0 – 25) | 0.85 |
| IgAN | 5.5 (3.3 – 8.8) | 0 (0 – 11) | 0.93 |
| C-PROBE | 2.0 (0 – 6.4) | 0 (0 – 29) | 0.86 |
| Diabetic nephropathy | 0.5 (0 – 4.6) | 0 (0 – 27) | 0.90 |
| CAKUT | 0.3 (0 – 3.1) | 0 (0 – 0) | 0.82 |
| Glomerular disease | 3.5 (0 – 9.2) | 0 (0 – 33) | 0.83 |
| Hypertensive nephropathy | 2.1 (0 – 6.2) | 0 (0 – 29) | 0.85 |
| Other/Unknown | 1.7 (0 – 4.6) | 0 (0 – 25) | 0.89 |
Unless otherwise indicated, values shown are median (interquartile range).
*
For NEPTUNE and C-PROBE data: estimated from linear generalized estimating equation model
**
SD for simulations; RMSE for NEPTUNE data.
NEPTUNE, Nephrotic Syndrome Study Network; C-PROBE, Clinical Phenotyping and Resource Biobank Core; SD: standard deviation; RMSE: root mean squared error; MN: membranous nephropathy, MCD: minimal change disease, FSGS: focal segmental glomerularsclerosis, IgAN: immunoglobulin A nephropathy; CAKUT: congenital anomalies of the kidney and urinary tract.