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. Author manuscript; available in PMC: 2018 Dec 28.
Published in final edited form as: Cell Rep. 2018 Jun 12;23(11):3209–3222. doi: 10.1016/j.celrep.2018.05.028

Figure 3. L3mbtl1 Is Required for Homeostatic Downscaling in Hippocampal CA3 Synapses.

Figure 3.

(A–C) Organotypic hippocampal slice cultures of wild-type or L3mbtl1−/− mice were treated with PTX or DMSO for 48 hr. mEPSC were recorded from CA3 pyramidal neurons.

(A) Representative mEPSC traces (left) and average mEPSC event traces (right) are shown.

(B) Cumulative distribution of mEPSC amplitudes. KS tests for distributions in wild-type group: ctrl versus PTX, p = 2.8 × 10−11; scaled ctrl versus PTX, not significant.

(C) Mean mEPSC amplitude (left) and frequency (right).

*p < 0.05, ns, not significant; two-way ANOVA test; N = 6 mice were tested. Data shown are means ± SEM.