Fig. 1.

Roadmap of the CAM-CM method (illustrated on the special case of J = 3). A hybrid multivariate clustering first groups the normalized pixel time courses into “local” clusters that correspond to either pure-volume or partial-volume pixels. The CAM-CM then separates the pure-volume clusters from partial-volume clusters by detecting the corners of the clustered convex hull. The identified pure-volume cluster centers and their associated pixels are further used to estimate the tissue-specific kinetic parameters within the tumor site by compartment modeling globally and locally.