Table 3.
Partial correlation between scene-encoding task CBF (task CBF), resting CBF, structural measurements and estimated rate of hippocampal atrophy in a-MCI (controlling for age), normal controls (controlling for age) and the whole cohort (controlling for age and sex). For the whole cohort, sex was included as an additional covariate due to the unmatched sex ratio between a-MCI and normal controls. Significant correlations were highlighted in bold font and the ones survived Bonferroni correlation (p < 0.05/6) were highlighted by star signs. 95% confidence intervals were reported in parentheses. Including sex as an additional covariate for within group analyses (a-MCI and normal controls) did not significantly affect the results, shown in Supplementary Table S1. When testing on subjects with all the three kinds of measurements available, the results were similar.
| Group | ROI | Task CBF | Resting CBF | Structural Measurements |
|---|---|---|---|---|
| a-MCI | Number of Subjects | 27 | 28 | 29 |
| Gray Matter |
r = 0.49 (0.11, 0.73) p = 0.012 |
r = 0.12 (−0.32, 0.49) p = 0.547 |
r = 0.15 (−0.31, 0.54) p = 0.454 |
|
| Hippocampus |
r = 0.36 (−0.01, 0.60) p = 0.068 |
r = 0.10 (−0.35, 0.37) p = 0.962 |
r = 0.07 (−0.25, 0.41) p = 0.710 |
|
| PCC |
r = 0.37 (−0.03, 0.71) p = 0.063 |
r = 0.15 (−0.35, 0.53) p = 0.440 |
r = 0.00 (−0.36, 0.36) p = 0.993 |
|
| Precuneus |
r = 0.15 (−0.35, 0.57) p = 0.469 |
r = 0.21 (−0.30, 0.60) p = 0.300 |
r = −0.09 (−0.47, 0.41) p = 0.666 |
|
| Fusiform Gyrus |
r = 0.56 (0.15, 0.77) p = 0.003* |
r = 0.06 (−0.38, 0.43) p = 0.770 |
r = 0.11 (−0.40, 0.60) p = 0.584 |
|
| Parahippocampal Gyrus |
r = 0.33 (−0.07, 0.63) p = 0.102 |
r = −0.05 (−0.38, 0.33) p = 0.816 |
r = 0.20 (−0.25, 0.59) p = 0.320 |
|
| Whole Cohort | Number of Subjects | 62 | 68 | 70 |
| Gray Matter |
r = 0.26 (0.07, 0.44) p = 0.045 |
r = 0.15 (0.03, 0.31) p = 0.233 |
r = 0.00 (−0.23, 0.23) p = 0.980 |
|
| Hippocampus |
r = 0.36 (0.15, 0.54) p = 0.005 * |
r = 0.11 (−0.11, 0.31) p = 0.386 |
r = 0.24 (0.04, 0.43) p = 0.048 |
|
| PCC |
r = 0.19 (0.06, 0.39) p = 0.151 |
r = 0.21 (0.01, 0.40) p = 0.090 |
r = 0.01 (−0.21, 0.25) p = 0.909 |
|
| Precuneus |
r = 0.12 (−0.09, 0.33) p = 0.348 |
r = 0.23 (0.01, 0.44) p = 0.067 |
r = −0.09 (−0.28, 0.10) p = 0.463 |
|
| Fusiform Gyrus |
r = 0.31 (0.08, 0.51) p = 0.018 |
r = 0.11 (−0.09, 0.29) p = 0.397 |
r = 0.05 (−0.20, 0.31) p = 0.679 |
|
| Parahippocampal Gyrus |
r = 0.30 (0.07, 0.51) p = 0.021 |
r = 0.08 (−0.13, 0.28) p = 0.542 |
r = 0.24 (0.01, 0.47) p = 0.045 |
|
| NC | Number of Subjects | 35 | 40 | 41 |
| Gray Matter |
r = 0.26 (0.02, 0.47) p = 0.139 |
r = 0.26 (0.01, 0.48) p = 0.103 |
r = −0.31 (−0.53, −1.0) p = 0.051 |
|
| Hippocampus |
r = 0.33 (0.02, 0.58) p = 0.057 |
r = 0.28 (−0.03, 0.50) p = 0.084 |
r = 0.15 (−0.24, 0.48) p = 0.356 |
|
| PCC |
r = 0.15 (−0.16, 0.40) p = 0.390 |
r = 0.25 (−0.05, 0.50) p = 0.118 |
r = −0.10 (−0.38, 0.20) p = 0.545 |
|
| Precuneus |
r = 0.17 (−0.09, 0.40) p = 0.348 |
r = 0.27 (−0.05, 0.52) p = 0.100 |
r = −0.12 (−0.37, 0.11) p = 0.446 |
|
| Fusiform Gyrus |
r = 0.25 (−0.01, 0.49) p = 0.145 |
r = 0.22 (0.00, 0.41) p = 0.176 |
r = −0.08 (−0.37, 0.20) p = 0.646 |
|
| Parahippocampal Gyrus |
r = 0.25 (−0.01, 0.50) p = 0.150 |
r = 0.25 (0.00, 0.46) p = 0.105 |
r = −0.01 (−0.36, 0.30) p = 0.956 |
|
Note: = p < 0.05,
= p < 0.01, indicate significant effects after corrected for multiple comparisons. PCC = posterior cingulate cortex. ROI = region of interest. CBF = cerebral blood flow. a-MCI = amnestic mild cognitive impairment. NC = normal control.