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. 2018 Dec 21;12:106. doi: 10.3389/fncir.2018.00106

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Copyright © 2018 Hökfelt, Barde, Xu, Kuteeva, Rüegg, Le Maitre, Risling, Kehr, Ihnatko, Theodorsson, Palkovits, Deakin, Bagdy, Juhasz, Prud’homme, Mechawar, Diaz-Heijtz and Ögren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time of immobility (A) and climbing (B) in the forced swim test (FST). Rats received i.c.v. infusion of aCSF, galanin (Gal), the GalR1 receptor agonist M617, the GalR2(R3) agonist AR-M1896 or the GalR2 antagonist M871 (M871) 20 min prior to a 5 min test. Data presented as mean ^±SEM. significant difference from the control swim group; ^∗one-way ANOVA, Fisher’s PLSD. Galanin, the GalR1 agonist and the GalR2 antagonist increase the immobility time versus a decrease after the GalR2(3) agonist. From Kuteeva et al. (2008), with permission.