Table 1.
(A,B) Concentration of galanin peptide (pmol/mg ± SEM) analyzed by RIA (A) and raw Ct values ± SEM monitored by qPCR (B) for male and female control and suicide samples from five brain regions.
| DLPFC | ACC | DRN | LC | MRN | |
|---|---|---|---|---|---|
| (A) Region | |||||
| Male Con | 3.9 ± 1.2 | 5.4 ± 1.2 | 61.6 ± 13.7 | 31.8 ± 7.5 | 15.6 ± 2.3 |
| Male DS | 2.7 ± 0.5 | 4.9 ± 1.0 | 68.1 ± 11.6 | 37.4 ± 10.7 | 18.7 ± 4.8 |
| Female Con | 1.7 ± 0.4 | 6.4 ± 1.8 | 80.6 ± 10.2 | 43.4 ± 6.3 | 15.5 ± 3.5 |
| Female DS | 1.3 ± 0.3 | 6.0 ± 1.3 | 81.6 ± 5.2 | 67.7 ± 7.5 | 13.5 ± 2.9 |
| (B) Region | |||||
| Galanin | 27.1 ± 0.2 | 27.5 ± 0.1 | 26.2 ± 0.4 | 24.6 ± 0.5 | 25.2 ± 0.4 |
| GalR1 | 25.7 ± 0.2 | 28.6 ± 0.1 | 27.0 ± 0.4 | 26.4 ± 0.6 | 26.9 ± 0.4 |
| GalR2 | 31.4 ± 0.2 | 31.6 ± 0.2 | 29.3 ± 0.2 | 32.3 ± 0.1 | 34.6 ± 0.2 |
| GalR3 | 33.2 ± 0.1 | 33.5 ± 0.2 | 31.5 ± 0.4 | 31.4 ± 0.6 | 31.9 ± 0.4 |
From Barde et al. (2016). Con, controls, DS, depressed suicides; DLPFC, dorsolateral prefrontal cortex; ACC, anterior cingulate cortex; DRN, dorsal raphe nucleus; LC, locus coeruleus; MRN, medullary raphe nuclei; Gal, galanin. Italics indicate significantly lower galanin levels in male vs. female depressed suicides.