Table 2.
Overview of mRNA and DNA methylation changes.
| Galanin |
GalRl |
GalR2 |
GalR3 |
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IDNA methylation |
gDNA methylation |
gDNA methylation |
gDNA methylation |
||||||||||||||||
| Regions | Sex | mRNA | CpGl | CpG2 | CpG3 | mRNA | CpGl | CpG2 | CpG3 | CpG4 | mRNA | CpGl | CpG2 | CpG3 | CpG4 | mRNA | CpGl | CpG2 | CpG3 |
| DLPFC | Males | ↓↓ | ↑ | ↑↑ | ↑ | – | – | – | – | – | – | – | – | – | ↓↓ | – | – | – | |
| Females | ↑ | ↑ | ↓ | – | ↑ | – | – | – | – | – | – | – | – | – | – | – | – | – | |
| ACC | Males | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Females | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
| DRN | Males | ↑↑ | – | ↓ | – | ↑ | – | – | – | – | – | – | – | – | – | ↑ | – | – | – |
| Females | ↑↑ | – | – | – | – | – | – | – | – | – | – | – | – | – | ↑↑ | ↓↓ | ↓↓ | – | |
| LC | Males | ↑↑ | ↓↓ | ↓ | – | – | – | – | – | – | – | – | – | – | – | ↑ | ↓ | – | – |
| Females | ↑↑ | ↓ | ↓↓ | – | – | – | – | – | – | – | – | – | – | – | ↑↑ | ↓ | ↓↓ | – | |
| MRN | Males | ↑ | – | – | – | ↑ | – | – | – | – | ↓↓ | – | – | – | – | ↑ | – | – | – |
| Females | ↑ | – | – | – | – | – | – | – | – | – | – | – | – | – | ↑ | – | – | – | |
From Barde et al. (2016). The arrows represent statistical significance, where upward arrow signifies increase in gene expression and methylation status and vice-versa. One arrow signifies P < 0.05 and two arrows stand for P < 0.01. DLPFC, dorsolateral prefrontal cortex; ACC, anterior cingulate cortex; DRN, dorsal raphe nucleus; LC, locus coeruleus; MRN, medullary raphe nuclei.