Skip to main content
. Author manuscript; available in PMC: 2018 Dec 28.
Published in final edited form as: ChemMedChem. 2016 Mar 16;11(16):1709–1720. doi: 10.1002/cmdc.201600015

Table 3.

Effects of selected cHTC derivatives and reference 3 on the RT-associated RNase H function of p66wt/p51C280A HIV-1 RT.

Compd HIV-1 RNase H
IC50 [μM][a]
31 > 50
33 0.52 ± 0.01
3 0.24 ± 0.002
[a]

IC50: compound concentration required to inhibit the HIV-1 RT-associated RNase H activity by 50%. The table reports the average and standard deviation of three independent experiments, made in duplicate.