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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Behav Brain Res. 2018 Sep 23;359:709–718. doi: 10.1016/j.bbr.2018.09.015

Figure 2.

Figure 2.

Effect of A/S on CP-induced reinstatement in (A) CP-vehicle and (B) CP-A/S. statistical analysis revealed a significant increase in time spent in CP-paired chamber during the conditioning phase as compared to preconditioning phase. Moreover, time spent in CP-paired chamber was significantly increased as compared to vehicle-paired chamber after conditioning training. In addition, one prime dose of CP induced a seeking behavior and increased time spent in CP-paired chamber as compared to extinction test. Time spent in CP-paired chamber was significantly increased as compared to vehicle-paired chamber following the reinstatement test. (B) CP-A/S treated group: statistical analysis revealed significant conditioning effect of CP as compared to preconditioning test. In addition, time spent in CP-paired chamber was significantly increased as compared to vehicle-paired chamber after conditioning training. Following extinction phase, A/S administration successfully attenuated the CP-induced reinstatement. In addition, there was a significant reduction in time spent in the CP-paired chamber in the reinstatement test as compared to postconditioning test. (C) CP-Vehicle and CPA/S groups: statistical analysis revealed a significant decrease in time spent in CP-paired chamber in CP-A/S group as compared to CP-Vehicle group during reinstatement test. Values shown as means ± S.E.M. (* comparison between time spent in CP-paired chamber during different CPP phases, *p < 0.05, **p < 0.01, ***p < 0.001), (n = 6-9 for each group).