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The schematic illustration describes each experimental timeline. Experiment 1 investigated the effect of single prolonged (SPS) stress on the acquisition of Pavlovian conditioned approach (PCA) behavior. Experiment 2 investigated the effect of SPS on the expression of PCA as well as the acquisition, extinction, and cue-induced reinstatement of cocaine self-administration. Experiment 3 investigated the effect of SPS on K+-induced dopamine release in the nucleus accumbens.
